Makingphysiologycomputable.

A continuous-time multimodal foundation model for human physiology. The inference layer, not the sensor layer.

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0%
of drug candidates fail to reach patients after entering clinical trials
FDA, Tufts CSDD
$0.0B
average cost to bring a single drug to market
Tufts Center for Drug Development
0.0M
patients annually affected by adverse drug reactions in the US
JAMA Internal Medicine
The Problem

Drug development is broken at the biology layer.


Nine out of ten drugs that enter clinical trials never reach patients. The most common reason is not commercial — it is biological. Toxicity that was invisible at the target level becomes catastrophic at the system level.

Current models test compounds against isolated targets. The human body does not work that way. The liver talks to the heart. The kidney talks to the liver. A compound that looks clean in isolation can trigger a cascade no single-organ model will ever predict.

Lumos is building the physics engine for the human body — a foundation model trained on continuous physiological time-series that sees the whole system, not just the target.

Live signal modeling

PhysioFM reads the body
as a continuous signal.

Cardiac — ECG trace
Hepatic — enzyme flux
Renal — filtration rate
CNS — neural oscillation
PhysioFM

The inference layer for
human physiology.

01
Continuous-time modeling
Trained on physiological time-series across organ systems. Not snapshots — the full temporal signal of a living body at every resolution.
02
Multi-organ simulation
Models the coupled dynamics between liver, kidney, cardiovascular, and CNS. Toxicity cascades become predictable before they harm a patient.
03
Drug compound inference
Query the model with a compound. Get a full-system toxicity and pharmacokinetic profile — before any patient is ever exposed.
Our mission
“The problem is not that we lack data. The problem is that we have never had a model capable of reading it at the level of the whole organism. That is what we are building.”
The Team

Built by people who understand the problem.

Our team comes from Harvard, Princeton, Stanford, and UC Berkeley — with backgrounds spanning computational biology, machine learning, drug development, and patient-facing clinical care.

Blogs

Coming Soon

We're working on sharing our research and insights. Check back soon for updates on our work in computational physiology.

Join Us

We're building the team.

We are a small team working on a hard problem. If you have a background in ML systems, computational biology, pharmacokinetics, or clinical data — we want to hear from you.

Contact

Let's talk.

Whether you're an investor, a potential collaborator, a pharma partner, or someone who wants to work on this problem — reach out directly.